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Epilepsy, Behavioral Abnormalities, and Physiological Comorbidities in Syntaxin-Binding Protein 1 (STXBP1) Mutant Zebrafish

Mutations in the synaptic machinery gene syntaxin-binding protein 1, STXBP1 (also known as MUNC18-1), are linked to childhood epilepsies and other neurodevelopmental disorders. Zebrafish STXBP1 homologs (stxbp1a and stxbp1b) have highly conserved sequence and are prominently expressed in the larval...

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Vydáno v:PLoS One
Hlavní autoři: Grone, Brian P., Marchese, Maria, Hamling, Kyla R., Kumar, Maneesh G., Krasniak, Christopher S., Sicca, Federico, Santorelli, Filippo M., Patel, Manisha, Baraban, Scott C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786103/
https://ncbi.nlm.nih.gov/pubmed/26963117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151148
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