Opposite Neural Trajectories of Apolipoprotein E ϵ4 and ϵ2 Alleles with Aging Associated with Different Risks of Alzheimer's Disease

The apolipoprotein E (APOE) ϵ4 allele is a confirmed genetic risk factor and the APOE ϵ2 allele is a protective factor related to late-onset Alzheimer's disease (AD). Intriguingly, recent studies demonstrated similar brain function alterations between APOE ϵ2 and ϵ4 alleles, despite their oppos...

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Detalhes bibliográficos
Publicado no:Cereb Cortex
Main Authors: Shu, Hao, Shi, Yongmei, Chen, Gang, Wang, Zan, Liu, Duan, Yue, Chunxian, Ward, B. Douglas, Li, Wenjun, Xu, Zhan, Chen, Guangyu, Guo, Qihao, Xu, Jun, Li, Shi-Jiang, Zhang, Zhijun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785940/
https://ncbi.nlm.nih.gov/pubmed/25336599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhu237
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