Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative

BACKGROUND: The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute’s human tumour cell line panel (NCI60). The mechanism of the anti-proliferati...

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Detalhes bibliográficos
Publicado no:Cancer Cell Int
Main Authors: Reynisson, Jóhannes, Jaiswal, Jagdish K., Barker, David, D’mello, Stacey A. N., Denny, William A., Baguley, Bruce C., Leung, Euphemia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785615/
https://ncbi.nlm.nih.gov/pubmed/26966420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-016-0293-6
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