Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants

Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the pathophysiological importance of the prototypical ac...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Molins, Blanca, Fuentes-Prior, Pablo, Adán, Alfredo, Antón, Rosa, Arostegui, Juan I., Yagüe, Jordi, Dick, Andrew D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785391/
https://ncbi.nlm.nih.gov/pubmed/26961257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22889
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