Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice

Epilepsy is a frequent comorbidity in patients with focal cortical dysplasia (FCD). Recent studies utilizing massive sequencing data identified subsets of genes that are associated with epilepsy and FCD. AKT and mTOR-related signals have been recently implicated in the pathogenic processes of epilep...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Matsushita, Yuki, Sakai, Yasunari, Shimmura, Mitsunori, Shigeto, Hiroshi, Nishio, Miki, Akamine, Satoshi, Sanefuji, Masafumi, Ishizaki, Yoshito, Torisu, Hiroyuki, Nakabeppu, Yusaku, Suzuki, Akira, Takada, Hidetoshi, Hara, Toshiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785342/
https://ncbi.nlm.nih.gov/pubmed/26961412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22991
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