Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

The breast cancer susceptibility gene BRCA1 is well known for its function in double-strand break (DSB) DNA repair. While BRCA1 is also implicated in transcriptional regulation, the physiological significance remains unclear. COBRA1 (also known as NELF-B) is a BRCA1-binding protein that regulates RN...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Nair, Sreejith J., Zhang, Xiaowen, Chiang, Huai-Chin, Jahid, Md Jamiul, Wang, Yao, Garza, Paula, April, Craig, Salathia, Neeraj, Banerjee, Tapahsama, Alenazi, Fahad S., Ruan, Jianhua, Fan, Jian-Bing, Parvin, Jeffrey D., Jin, Victor X., Hu, Yanfen, Li, Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785232/
https://ncbi.nlm.nih.gov/pubmed/26941120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10913
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