Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD

Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration. However, no pharmaceutical agent in twenty years has extended lifespan by more than a few weeks. The Copper-Chaperone-for-SOD (CCS) protein completes...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Williams, Jared R., Trias, Emiliano, Beilby, Pamela R., Lopez, Nathan I., Labut, Edwin M., Bradford, C. Samuel, Roberts, Blaine R., McAllum, Erin J., Crouch, Peter J., Rhoads, Timothy W., Pereira, Cliff, Son, Marjatta, Elliott, Jeffrey L., Franco, Maria Clara, Estévez, Alvaro G., Barbeito, Luis, Beckman, Joseph S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785045/
https://ncbi.nlm.nih.gov/pubmed/26826269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2016.01.020
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