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Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis

Limited data exist on the pharmacokinetic-pharmacodynamic (PK-PD) parameters of the bactericidal activities of the available antimycobacterial drugs. We report on the PK-PD relationships for isoniazid. Isoniazid exhibited concentration (C)-dependent killing of Mycobacterium tuberculosis H37Rv in vit...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Jayaram, Ramesh, Shandil, Radha. K., Gaonkar, Sheshagiri, Kaur, Parvinder, Suresh, B. L., Mahesh, B. N., Jayashree, R., Nandi, Vrinda, Bharath, Sowmya, Kantharaj, E., Balasubramanian, V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC478500/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15273105/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.8.2951-2957.2004
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