Tolerability and Pharmacokinetic Evaluation of Inhaled Dry Powder Tobramycin Free Base in Non-Cystic Fibrosis Bronchiectasis Patients

RATIONALE: Bronchiectasis is a condition characterised by dilated and thick-walled bronchi. The presence of Pseudomonas aeruginosa in bronchiectasis is associated with a higher hospitalisation frequency and a reduced quality of life, requiring frequent and adequate treatment with antibiotics. OBJECT...

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Pubblicato in:PLoS One
Autori principali: Hoppentocht, Marcel, Akkerman, Onno W., Hagedoorn, Paul, Alffenaar, Jan-Willem C., van der Werf, Tjip S., Kerstjens, Huib A. M., Frijlink, Henderik W., de Boer, Anne H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784940/
https://ncbi.nlm.nih.gov/pubmed/26959239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149768
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