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In Vitro Activity and Potency of an Intravenously Injected Antimicrobial Peptide and Its dl Amino Acid Analog in Mice Infected with Bacteria
We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% d amino acids) of an antimicrobial peptide, K(6)L(9) (LKLLKKLLKKLLKLL-NH(2)), but not the all-l-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomon...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC478488/ https://ncbi.nlm.nih.gov/pubmed/15273131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.3127-3129.2004 |
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