Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis

Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis, INH requires activation by the catalase-peroxidase KatG, converting INH from its prodrug form into a range of bactericidal reactive species. Here we used (15)N-labeled INH together w...

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Detalhes bibliográficos
Main Authors: Timmins, Graham S., Master, Sharon, Rusnak, Frank, Deretic, Vojo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC478481/
https://ncbi.nlm.nih.gov/pubmed/15273113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.3006-3009.2004
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