Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Complement component C3 has a potential role in thrombotic pathologies. It is transformed, without proteolytic cleavage, into C3(H(2)O) upon binding to the surface of activated platelets. We hypothesise that C3(H(2)O) bound to activated platelets and to platelet-derived microparticles (PMPs) contrib...

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Bibliografski detalji
Izdano u:Thromb Haemost
Glavni autori: Hamad, Osama A., Mitroulis, Ioannis, Fromell, Karin, Kozarcanin, Huda, Chavakis, Triantafyllos, Ricklin, Daniel, Lambris, John D., Ekdahl, Kristina N., Nilsson, Bo
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784683/
https://ncbi.nlm.nih.gov/pubmed/26293614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH15-02-0162
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