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Concise Synthesis of Capuramycin
A concise total synthesis of capuramycin (1), a promising preclinical TB drug lead, is achieved by high-yield formations of the cyanohydrin 5a and 4″,5″-glycal derivative 12. Capuramycin can be synthesized in eight steps from the uridine building block 5a with >30% overall yield. The synthetic in...
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| Gepubliceerd in: | Org Lett |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2009
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4784474/ https://ncbi.nlm.nih.gov/pubmed/19405507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol900458w |
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