Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association

BACKGROUND: Coronin-1A (CORO1A) is a regulator of actin dynamics important for T cell homeostasis. CORO1A deficiency causes T(−)B(+)NK(+) severe combined immunodeficiency or T cell lymphopenia with severe viral infections. However, since all known human mutations in CORO1A abrogate protein expressio...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Yee, Christina S., Massaad, Michel J., Bainter, Wayne, Ohsumi, Toshiro K., Föger, Niko, Chan, Andrew C., Akarsu, Nurten A., Aytekin, Caner, Ayvaz, Deniz Çagdas, Tezcan, Ilhan, Sanal, Özden, Geha, Raif S., Chou, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783242/
https://ncbi.nlm.nih.gov/pubmed/26476480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.08.020
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