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Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death

La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal da...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Immunity
Hauptverfasser: Mukherjee, Piyali, Woods, Tyson A., Moore, Roger A., Peterson, Karin E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783152/
https://ncbi.nlm.nih.gov/pubmed/23499490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.02.013
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