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Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of metabolism, changes in TH signaling have widespre...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Visser, W. Edward, Bombardieri, Cíntia R., Zevenbergen, Chantal, Barnhoorn, Sander, Ottaviani, Alexandre, van der Pluijm, Ingrid, Brandt, Renata, Kaptein, Ellen, van Heerebeek, Ramona, van Toor, Hans, Garinis, George A., Peeters, Robin P., Medici, Marco, van Ham, Willy, Vermeij, Wilbert P., de Waard, Monique C., de Krijger, Ronald R., Boelen, Anita, Kwakkel, Joan, Kopchick, John J., List, Edward O., Melis, Joost P. M., Darras, Veerle M., Dollé, Martijn E. T., van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., Visser, Theo J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783069/
https://ncbi.nlm.nih.gov/pubmed/26953569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149941
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