The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors

The mdx mouse is a good genetic and molecular murine model for Duchenne Muscular Dystrophy (DMD), a progressive and devastating muscle disease. However, this model is inappropriate for testing new therapies due to its mild phenotype. Here, we transferred the mdx mutation to the 129/Sv strain with th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Calyjur, Priscila Clara, Almeida, Camila de Freitas, Ayub-Guerrieri, Danielle, Ribeiro, Antonio Fernando, Fernandes, Stephanie de Alcântara, Ishiba, Renata, dos Santos, Andre Luis Fernandes, Onofre-Oliveira, Paula, Vainzof, Mariz
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783004/
https://ncbi.nlm.nih.gov/pubmed/26954670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150748
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