Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity

Multiple studies have indicated that in addition to direct oncolysis, virotherapy promotes an antitumor cytotoxic T cell response important for efficacy. To study this phenomenon further, we tested three syngeneic murine sarcoma models that displayed varied degrees of permissiveness to oncolytic her...

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Bibliographic Details
Published in:Mol Ther Oncolytics
Main Authors: Leddon, Jennifer L, Chen, Chun-Yu, Currier, Mark A, Wang, Pin-Yi, Jung, Francesca A, Denton, Nicholas L, Cripe, Kevin M, Haworth, Kellie B, Arnold, Michael A, Gross, Amy C, Eubank, Timothy D, Goins, William F, Glorioso, Joseph C, Cohen, Justus B, Grandi, Paola, Hildeman, David A, Cripe, Timothy P
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782947/
https://ncbi.nlm.nih.gov/pubmed/27119100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2014.10
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