Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity

Multiple studies have indicated that in addition to direct oncolysis, virotherapy promotes an antitumor cytotoxic T cell response important for efficacy. To study this phenomenon further, we tested three syngeneic murine sarcoma models that displayed varied degrees of permissiveness to oncolytic her...

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Publicat a:Mol Ther Oncolytics
Autors principals: Leddon, Jennifer L, Chen, Chun-Yu, Currier, Mark A, Wang, Pin-Yi, Jung, Francesca A, Denton, Nicholas L, Cripe, Kevin M, Haworth, Kellie B, Arnold, Michael A, Gross, Amy C, Eubank, Timothy D, Goins, William F, Glorioso, Joseph C, Cohen, Justus B, Grandi, Paola, Hildeman, David A, Cripe, Timothy P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782947/
https://ncbi.nlm.nih.gov/pubmed/27119100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2014.10
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