Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis

BACKGROUND: Secretion of proteopathic α-synuclein (α-SNC) species from neurons is a suspected driving force in the propagation of Parkinson’s disease (PD). We have previously implicated exophagy, the exocytosis of autophagosomes, as a dominant mechanism of α-SNC secretion in differentiated PC12 or S...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Christensen, Dan Ploug, Ejlerskov, Patrick, Rasmussen, Izabela, Vilhardt, Frederik
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782388/
https://ncbi.nlm.nih.gov/pubmed/26957005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0519-5
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