Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis

BACKGROUND: Secretion of proteopathic α-synuclein (α-SNC) species from neurons is a suspected driving force in the propagation of Parkinson’s disease (PD). We have previously implicated exophagy, the exocytosis of autophagosomes, as a dominant mechanism of α-SNC secretion in differentiated PC12 or S...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Neuroinflammation
Egile Nagusiak: Christensen, Dan Ploug, Ejlerskov, Patrick, Rasmussen, Izabela, Vilhardt, Frederik
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2016
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782388/
https://ncbi.nlm.nih.gov/pubmed/26957005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0519-5
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