Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model

BACKGROUND: Group IVA cytosolic phospholipase A2 (cPLA2α) plays an important role in tumorigenesis and angiogenesis. It is overexpressed in basal-like breast cancer (BLBC), which is aggressive and usually triple-negative, making it unresponsive to current targeted therapies. Here, we evaluated the a...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Kim, Eugene, Tunset, Hanna Maja, Cebulla, Jana, Vettukattil, Riyas, Helgesen, Heidi, Feuerherm, Astrid Jullumstrø, Engebråten, Olav, Mælandsmo, Gunhild Mari, Johansen, Berit, Moestue, Siver Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782288/
https://ncbi.nlm.nih.gov/pubmed/26951085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2225-1
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