Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A

Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-dependent protein kinase A (PKA) and ATP-regulated chloride channel. Here, we demonstrate that nucleoside diphosphate kinase B (NDPK-B, NM23-H2) forms a functional complex with CFTR. In a...

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發表在:PLoS One
Main Authors: Borthwick, Lee A., Kerbiriou, Mathieu, Taylor, Christopher J., Cozza, Giorgio, Lascu, Ioan, Postel, Edith H., Cassidy, Diane, Trouvé, Pascal, Mehta, Anil, Robson, Louise, Muimo, Richmond
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780765/
https://ncbi.nlm.nih.gov/pubmed/26950439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149097
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