A 5-fluorouracil-loaded floating gastroretentive hollow microsphere: development, pharmacokinetic in rabbits, and biodistribution in tumor-bearing mice

5-Fluorouracil (5-FU) was loaded in hollow microspheres to improve its oral bioavailability. 5-FU hollow microspheres were developed by a solvent diffusion–evaporation method. The effect of Span 80 concentration, ether/ethanol volume ratio, and polyvinyl pyrrolidone/ethyl cellulose weight ratio on p...

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Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Huang, Yu, Wei, Yumeng, Yang, Hongru, Pi, Chao, Liu, Hao, Ye, Yun, Zhao, Ling
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2016
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780720/
https://ncbi.nlm.nih.gov/pubmed/27042001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S97735
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