Plasmodium-infected erythrocytes (pRBC) induce endothelial cell apoptosis via a heme-mediated signaling pathway

Heme is cytotoxic to the plasmodium parasite, which converts it to an insoluble crystalline form called hemozoin (malaria pigment) in erythrocytes during replication. The increased serum levels of free heme cause tissue damage, activation of microvascular endothelial and glial cells, focal inflammat...

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Bibliographic Details
Published in:Drug Des Devel Ther
Main Authors: Liu, Mingli, Dickinson-Copeland, Carmen, Hassana, Salifu, Stiles, Jonathan K
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2016
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780719/
https://ncbi.nlm.nih.gov/pubmed/27042002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S96863
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