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Load-dependent destabilization of the γ-rotor shaft in F(O)F(1) ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometry
F(o)F(1) is a membrane-bound molecular motor that uses proton-motive force (PMF) to drive the synthesis of ATP from ADP and P(i). Reverse operation generates PMF via ATP hydrolysis. Catalysis in either direction involves rotation of the γε shaft that connects the α(3)β(3) head and the membrane-ancho...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780623/ https://ncbi.nlm.nih.gov/pubmed/26884184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520464113 |
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