Germinal Center T Follicular Helper Cells (GC T(FH)) are Highly Permissive to HIV-1 and Alter Their Phenotype During Virus Replication

HIV-1 replication is concentrated within CD4+ T cells in B-cell follicles of secondary lymphoid tissues during asymptomatic disease. Limited data suggest that a subset of T follicular helper cells (T(FH)) within germinal centers (GC) is highly permissive to HIV-1. Whether GC T(FH) are the major HIV-...

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Pubblicato in:J Immunol
Autori principali: Kohler, Stephanie L., Pham, Michael N., Folkvord, Joy M., Arends, Tessa, Miller, Shannon M., Miles, Brodie, Meditz, Amie L., McCarter, Martin, Levy, David N., Connick, Elizabeth
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779697/
https://ncbi.nlm.nih.gov/pubmed/26873986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502174
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