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NK Cell Maturation and Cytotoxicity are Controlled by the Intramembrane Aspartyl Protease SPPL3()

NK cell maturation is critical for normal effector function and the innate immune response to tumors and pathogens. However, the molecular pathways that control NK cell maturation remain largely undefined. Here, we investigate the role of SPPL3, an intramembrane aspartyl protease, in murine NK cell...

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Pubblicato in:J Immunol
Autori principali: Hamblet, Corinne E., Makowski, Stefanie L., Tritapoe, Julia M., Pomerantz, Joel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779696/
https://ncbi.nlm.nih.gov/pubmed/26851218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501970
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