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Characterization of IXINITY® (Trenonacog Alfa), a Recombinant Factor IX with Primary Sequence Corresponding to the Threonine-148 Polymorph

The goal of these studies was to extensively characterize the first recombinant FIX therapeutic corresponding to the threonine-148 (Thr-148) polymorph, IXINITY (trenonacog alfa [coagulation factor IX (recombinant)]). Gel electrophoresis, circular dichroism, and gel filtration were used to determine...

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書目詳細資料
發表在:Adv Hematol
Main Authors: Monroe, Dougald M., Jenny, Richard J., Van Cott, Kevin E., Buhay, Shelly, Saward, Laura L.
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779506/
https://ncbi.nlm.nih.gov/pubmed/26997955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/7678901
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