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DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States

RATIONALE: Only a small portion of the known heritability of cardiovascular diseases such as heart failure can be explained based on single gene mutations. Chromatin structure and regulation provide a substrate through which genetic differences in non-coding regions may impact cellular function and...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Chen, Haodong, Orozco, Luz, Wang, Jessica, Rau, Christoph D., Rubbi, Liudmilla, Ren, Shuxun, Wang, Yibin, Pellegrini, Matteo, Lusis, Aldons J., Vondriska, Thomas M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779427/
https://ncbi.nlm.nih.gov/pubmed/26838786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.305298
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