Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells

Protein phosphatase 2A (PP2A) is one of the major serine/threonine phosphatases. We hypothesize that PP2A regulates signaling cascades in pancreatic β-cells in the context of glucose-stimulated insulin secretion (GSIS). Using co-immunoprecipitation (co-IP) and tandem mass spectrometry, we globally i...

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Pubblicato in:Mol Cell Endocrinol
Autori principali: Zhang, Xiangmin, Damacharla, Divyasri, Ma, Danjun, Qi, Yue, Tagett, Rebecca, Draghici, Sorin, Kowluru, Anjaneyulu, Yi, Zhengping
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779412/
https://ncbi.nlm.nih.gov/pubmed/26780722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2016.01.008
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