Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway

BACKGROUND: Hypoxia exposure is known to induce an alteration in skeletal muscle fiber-type distribution mediated by hypoxia-inducible factor (HIF)-α. The downstream pathway of HIF-α leading to fiber-type shift, however, has not been elucidated. The calcineurin pathway is one of the pathways respons...

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Bibliografiska uppgifter
I publikationen:Skelet Muscle
Huvudupphovsmän: Shin, Junchul, Nunomiya, Aki, Kitajima, Yasuo, Dan, Takashi, Miyata, Toshio, Nagatomi, Ryoichi
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779261/
https://ncbi.nlm.nih.gov/pubmed/26949511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-016-0079-5
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