Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia

Human APOBEC3 cytidine deaminases are intrinsic resistance factors to HIV-1. However, HIV-1 encodes a viral infectivity factor (Vif) that degrades APOBEC3 proteins. In vitro APOBEC3F (A3F) anti-HIV-1 activity is weaker than A3G but is partially resistant to Vif degradation unlike A3G. It is unknown...

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Udgivet i:PLoS Genet
Main Authors: An, Ping, Penugonda, Sudhir, Thorball, Christian W., Bartha, Istvan, Goedert, James J., Donfield, Sharyne, Buchbinder, Susan, Binns-Roemer, Elizabeth, Kirk, Gregory D., Zhang, Wenyan, Fellay, Jacques, Yu, Xiao-Fang, Winkler, Cheryl A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778847/
https://ncbi.nlm.nih.gov/pubmed/26942578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005921
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