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The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor

The binding process through the membrane bilayer of lipid-like ligands to a protein target is an important but poorly explored recognition process at the atomic level. In this work we succeeded in resolving the binding of the lipid inhibitor ML056 to the sphingosine-1-phosphate receptor 1 (S1P(1)R)...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Stanley, Nathaniel, Pardo, Leonardo, Fabritiis, Gianni De
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778059/
https://ncbi.nlm.nih.gov/pubmed/26940769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22639
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