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Oral Immunization of Rabbits with S. enterica Typhimurium Expressing Neisseria gonorrhoeae Filamentous Phage Φ6 Induces Bactericidal Antibodies Against N. gonorrhoeae

All Neisseria gonorrhoeae strains whose DNA sequences have been determined possess filamentous phage DNA sequences. To ascertain if phage encoded proteins could form the basis of a gonococcal vaccine, rabbits were orally infected with S. enterica Typhimurium strain χ3987 harboring phagemid NgoΦ6 fm....

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Publicat a:Sci Rep
Autors principals: Piekarowicz, Andrzej, Kłyż, Aneta, Majchrzak, Michał, Stein, Daniel C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778046/
https://ncbi.nlm.nih.gov/pubmed/26939573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22549
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