VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis

Unesterified cholesterol accumulates in late endosomes in cells expressing the misfolded cystic fibrosis transmembrane conductance regulator (CFTR). CFTR misfolding in the endoplasmic reticulum (ER) or general activation of ER stress led to dynein-mediated clustering of cholesterol-loaded late endos...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Ernst, Wayne L., Shome, Kuntala, Wu, Christine C., Gong, Xiaoyan, Frizzell, Raymond A., Aridor, Meir
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Protein Synthesis and Degradation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777854/
https://ncbi.nlm.nih.gov/pubmed/26740627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692749
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