VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis

Unesterified cholesterol accumulates in late endosomes in cells expressing the misfolded cystic fibrosis transmembrane conductance regulator (CFTR). CFTR misfolding in the endoplasmic reticulum (ER) or general activation of ER stress led to dynein-mediated clustering of cholesterol-loaded late endos...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Ernst, Wayne L., Shome, Kuntala, Wu, Christine C., Gong, Xiaoyan, Frizzell, Raymond A., Aridor, Meir
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777854/
https://ncbi.nlm.nih.gov/pubmed/26740627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692749
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