Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnα11-Coupled Receptor in Sertoli Cells

Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology. Here we show that at a physiological concentration (1 μM), DHEAS induces the phosphorylation of the kinase Erk1/2 and of the transcription factors CREB and ATF-1 in the m...

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Veröffentlicht in:PLoS One
Hauptverfasser: Papadopoulos, Dimitrios, Dietze, Raimund, Shihan, Mazen, Kirch, Ulrike, Scheiner-Bobis, Georgios
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777551/
https://ncbi.nlm.nih.gov/pubmed/26938869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150143
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