Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover

The α8 integrin (Itga8) chain contributes to the regulation of cell proliferation and apoptosis in renal glomerular cells. In unilateral ureteral obstruction Itga8 is de novo expressed in the tubulointerstitium and a deficiency of Itga8 results in more severe renal fibrosis after unilateral ureteral...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Marek, Ines, Lichtneger, Till, Cordasic, Nada, Hilgers, Karl F., Volkert, Gudrun, Fahlbusch, Fabian, Rascher, Wolfgang, Hartner, Andrea, Menendez-Castro, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777439/
https://ncbi.nlm.nih.gov/pubmed/26938996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150471
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