Assessment of Quantitative and Allelic MGMT Methylation Patterns as a Prognostic Marker in Glioblastoma

Methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene is a predictive and prognostic marker in newly diagnosed glioblastoma patients treated with temozolomide but how MGMT methylation should be assessed to ensure optimal detection accuracy is debated. We developed a novel quantitat...

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Publicat a:J Neuropathol Exp Neurol
Autors principals: Kristensen, Lasse S., Michaelsen, Signe R., Dyrbye, Henrik, Aslan, Derya, Grunnet, Kirsten, Christensen, Ib J., Poulsen, Hans S., Grønbæk, Kirsten, Broholm, Helle
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777218/
https://ncbi.nlm.nih.gov/pubmed/26883115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlv024
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