ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

The receptor tyrosine kinase-like orphan receptor 1 (ROR1) sustains prosurvival signalling directly downstream of the lineage-survival oncogene NKX2-1/TTF-1 in lung adenocarcinoma. Here we report an unanticipated function of this receptor tyrosine kinase (RTK) as a scaffold of cavin-1 and caveolin-1...

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Pubblicato in:Nat Commun
Autori principali: Yamaguchi, Tomoya, Lu, Can, Ida, Lisa, Yanagisawa, Kiyoshi, Usukura, Jiro, Cheng, Jinglei, Hotta, Naoe, Shimada, Yukako, Isomura, Hisanori, Suzuki, Motoshi, Fujimoto, Toyoshi, Takahashi, Takashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777216/
https://ncbi.nlm.nih.gov/pubmed/26725982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10060
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