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Early and multiple origins of metastatic lineages within primary tumors

Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such as the divergence times and genetic clonality of metastatic lineages. To address these challenges, we performed tumor phylogenetics using mole...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Zhao, Zi-Ming, Zhao, Bixiao, Bai, Yalai, Iamarino, Atila, Gaffney, Stephen G., Schlessinger, Joseph, Lifton, Richard P., Rimm, David L., Townsend, Jeffrey P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776530/
https://ncbi.nlm.nih.gov/pubmed/26858460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525677113
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