Ribosome Protein L4 is essential for Epstein–Barr Virus Nuclear Antigen 1 function

Epstein–Barr Virus (EBV) Nuclear Antigen 1 (EBNA1)-mediated origin of plasmid replication (oriP) DNA episome maintenance is essential for EBV-mediated tumorigenesis. We have now found that EBNA1 binds to Ribosome Protein L4 (RPL4). RPL4 shRNA knockdown decreased EBNA1 activation of an oriP luciferas...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shen, Chih-Lung, Liu, Cheng-Der, You, Ren-In, Ching, Yung-Hao, Liang, Jun, Ke, Liangru, Chen, Ya-Lin, Chen, Hong-Chi, Hsu, Hao-Jen, Liou, Je-Wen, Kieff, Elliott, Peng, Chih-Wen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776490/
https://ncbi.nlm.nih.gov/pubmed/26858444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525444113
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