Relative bioavailability, food effect, and safety of the single-dose pharmacokinetics of omecamtiv mecarbil following administration of different modified-release formulations in healthy subjects

Objective: Omecamtiv mecarbil is a novel small molecule that directly activates cardiac myosin and increases cardiac contractility without increasing cardiac myocyte intracellular calcium. This study evaluated the relative bioavailability, food effect, and safety of several modified-release (MR) for...

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Detalhes bibliográficos
Publicado no:Int J Clin Pharmacol Ther
Main Authors: Palaparthy, Rameshraja, Banfield, Christopher, Alvarez, Paco, Yan, Lucy, Smith, Brian, Johnson, Jessica, Monsalvo, Maria Laura, Malik, Fady
Formato: Artigo
Idioma:Inglês
Publicado em: Dustri-Verlag Dr. Karl Feistle 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776255/
https://ncbi.nlm.nih.gov/pubmed/26709596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5414/CP202458
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