In Vitro and in Vivo Evaluation of Mutations in the NS Region of Lineage 2 West Nile Virus Associated with Neuroinvasiveness in a Mammalian Model

West Nile virus (WNV) strains may differ significantly in neuroinvasiveness in vertebrate hosts. In contrast to genetic lineage 1 WNVs, molecular determinants of pathogenic lineage 2 strains have not been experimentally confirmed so far. A full-length infectious clone of a neurovirulent WNV lineage...

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Publicado en:Viruses
Autores principales: Szentpáli-Gavallér, Katalin, Lim, Stephanie M., Dencső, László, Bányai, Krisztián, Koraka, Penelope, Osterhaus, Albert D.M.E., Martina, Byron E.E., Bakonyi, Tamás, Bálint, Ádám
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776204/
https://ncbi.nlm.nih.gov/pubmed/26907325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v8020049
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