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Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction
The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to chronic inflammation and disease. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4776135/ https://ncbi.nlm.nih.gov/pubmed/26936329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22450 |
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