Treatment with a Nucleoside Polymerase Inhibitor Reduces Shedding of Murine Norovirus in Stool to Undetectable Levels without Emergence of Drug-Resistant Variants

Prolonged norovirus shedding may occur in certain patients, such as organ transplant recipients. We established a mouse model for persistent norovirus infection (using the mouse norovirus MNV.CR6 strain). The nucleoside viral polymerase inhibitor 2′-C-methylcytidine (2CMC), but not favipiravir (T-70...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Rocha-Pereira, Joana, Van Dycke, Jana, Neyts, Johan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776014/
https://ncbi.nlm.nih.gov/pubmed/26711754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02198-15
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