A novel synthetic compound MCAP suppresses LPS-induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways

AIM: To investigate the anti-neuroinflammatory activity of a novel synthetic compound, 7-methylchroman-2-carboxylic acid N-(2-trifluoromethyl) phenylamide (MCAP) against LPS-induced microglial activation in vitro. METHODS: Primary mouse microglia and BV2 microglia cells were exposed to LPS (50 or 10...

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Bibliografiska uppgifter
I publikationen:Acta Pharmacol Sin
Huvudupphovsmän: Kim, Byung-Wook, More, Sandeep Vasant, Yun, Yo-Sep, Ko, Hyun-Myung, Kwak, Jae-Hwan, Lee, Heesoon, Suk, Kyoungho, Kim, In-Su, Choi, Dong-Kug
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775849/
https://ncbi.nlm.nih.gov/pubmed/26838070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.138
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