Berberine protects rat heart from ischemia/reperfusion injury via activating JAK2/STAT3 signaling and attenuating endoplasmic reticulum stress

AIM: Berberine (BBR), an isoquinoline-derived alkaloid isolated from Rhizoma coptidis, exerts cardioprotective effects. Because endoplasmic reticulum (ER) stress plays a pivotal role in myocardial ischemia/reperfusion (MI/R)-induced apoptosis, it was interesting to examine whether the protective eff...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Zhao, Guo-long, Yu, Li-ming, Gao, Wen-li, Duan, Wei-xun, Jiang, Bo, Liu, Xu-dong, Zhang, Bin, Liu, Zhen-hua, Zhai, Meng-en, Jin, Zhen-xiao, Yu, Shi-qiang, Wang, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775848/
https://ncbi.nlm.nih.gov/pubmed/26806299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.136
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