DW10075, a novel selective and small-molecule inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo

AIM: Targeting the VEGF/VEGF receptor (VEGFR) pathway has proved to be an effective antiangiogenic approach for cancer treatment. Here, we identified 6-((2-((3-acetamidophenyl)amino)pyrimidin-4-yl)oxy)-N-phenyl-1-naphthamide (designated herein as DW10075) as a novel and highly selective inhibitor of...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Li, Meng-yuan, Lv, Yong-cong, Tong, Lin-jiang, Peng, Ting, Qu, Rong, Zhang, Tao, Sun, Yi-ming, Chen, Yi, Wei, Li-xin, Geng, Mei-yu, Duan, Wen-hu, Xie, Hua, Ding, Jian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775843/
https://ncbi.nlm.nih.gov/pubmed/26806300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.117
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